Manganese Superoxide Dismutase in Cancer Prevention
نویسندگان
چکیده
منابع مشابه
Manganese Superoxide Dismutase (MnSOD)
2 Introduction 3 Phylogenetic distribution and subcellular localization 3 Kinetics and mechanism 3 Molecular and chemical structure 5 Biological significance 8 Summary 9 References 10 Abstract Manganese superoxide dismutase (MnSOD) is the primary antioxidant enzyme that protects cells from oxidative stress by catalyzing dismutation of superoxide (O2 ) to hydrogen peroxide and oxygen in the mito...
متن کاملThe Role of Manganese Superoxide Dismutase in Skin Cancer
Recent studies have shown that antioxidant enzyme expression and activity are drastically reduced in most human skin diseases, leading to propagation of oxidative stress and continuous disease progression. However, antioxidants, an endogenous defense system against reactive oxygen species (ROS), can be induced by exogenous sources, resulting in protective effects against associated oxidative in...
متن کاملCatalase in Lung Cancer Differential Expression of Manganese Superoxide Dismutase
Reactive oxygen species (ROS) are important in the initiation and promotion of cells to neoplastic growth. In this context, cigarette smoke exposure, the primary risk factor in lung cancer development, leads to high levels of ROS within the human airway. Although well-equipped with an integrated antioxidant defense system consisting of low-molecular weight antioxidants such as glutathione and i...
متن کاملHuman Manganese Superoxide Dismutase Target Sequence Polymorphism and Ovarian Cancer
Antioxidant enzymes play a significant role in maintaining normal ROS level in the cell. Thus, their altered expression may result in harmful consequences. Manganese superoxide dismutase (MnSOD) is a primary antioxidant enzyme that neutralizes highly reactive mitochondrial superoxide radical (O2 −) to hydrogen peroxide (H2O2), which may be further neutralized by subsequent enzymes. Thus, MnSOD ...
متن کاملManganese Superoxide Dismutase: Guardian of the Heart
Submit Manuscript | http://medcraveonline.com MOJ Anat Physiol 2015, 1(2): 00006 was neonatal lethal. Due to background modifications, a small percentage of knockout mice showed dilated cardiomyopathy indicating increased vulnerability to oxidative injury in the cardiac myocytes [1]. Ikegami et al. [3] successfully generated tissuespecific MnSOD conditional knockout mice that would provide a us...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2014
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2013.5297